In "Extreme Risk", B'Elanna Torres tells Neelix that her grandmother used to make her banana pancakes with maple syrup and it always put a smile on her face. Neelix responds by replicating a stack of banana pancakes. "Well then," he says, "one smile coming right up."
In order to catch the traitorous Michael Eddington, Sisko launches a biogenic weapon composed of trilithium resin that poisons the atmosphere of a Maquis colony and forces Eddington to surrender. Needless to say, he doesn't clear this tactic with Starfleet.
In "Encounter at Farpoint", Q puts Picard and the Enterprise crew on trial, arguing that humanity is a dangerous race and should be destroyed. When they later save the life of a kidnapped alien, Q agrees to defer judgement, though he suggest this won't be his last word on the matter.
William Shatner's well-documented feud with former co-star George Takei simmered for decades. Both actors took jabs at each other during major media interviews, including on Howard Stern, Real Time with Bill Maher, and even in their autobiographies.