Miikka Kiprusoff finished the 2005-06 season with a 42-20-11 record and a team-record 10 shutouts. He was named a first team All-Star and awarded the Vezina Trophy, as well as the William M. Jennings Trophy for being the goaltender on the team that gave up the fewest goals during the season.

Fleury was drafted by the Flames in the 8th round, 166th overall, at the 1987 NHL Entry Draft, and played over 1,000 games in the NHL between 1989 and 2003.

Eric "Big Train" Vail led all rookies in 1974-75 with 39 goals and had 60 points, winning the Calder Memorial Trophy as the NHL's Rookie of the Year, the first player in Flames history to do so.

During his NHL career, Nilsson was called "Mr. Magic" or "The Magic Man", referring to his exceptional puck skills. Wayne Gretzky said of Nilsson "Skills-wise he might have been the most skilled hockey player I ever saw in my entire career."

Drafted 2nd overall by the Flames in 1972, Jacques Richard was considered a potential NHL superstar, but with the exception of a single season late in his career, he failed to live up to his promise.

Joe Mullen won the Lady Byng Memorial Trophy as the NHL's most gentlemanly player on two occasions as a member of the Flames, as well as the NHL Plus-Minus Award. Mullen was named to the First All-Star Team in 1988-89 and played in three NHL All-Star Games.

An undrafted player, Mark Giordano signed with the Flames as a free agent in 2004 after playing two seasons of major junior hockey with Owen Sound Attack of the Ontario Hockey League. He played his first NHL All-Star Game in 2015 and was awarded the James Norris Memorial Trophy as the NHL's best defenceman in 2019, at the age of 35.

Sean Monahan scored his 100th career goal against Andrei Vasilevskiy of the Tampa Bay Lightning on February 23, 2017, at the age of 22 years, 134 days, surpassing Joe Nieuwendyk, who was 22 years and 185 days old when he scored his 100th career goal.

In 1990-91, Sergei Makarov scored 30 goals on just 93 shots, for a franchise-record shooting percentage of 32.3%.

Joe Nieuwendyk set a Flames franchise record on January 11, 1989, when he scored five goals in one game against the Winnipeg Jets.