The show is set in a bar in Boston, Massachusetts.

Before the series began, he was a relief pitcher for the Red Sox nicknamed "Mayday Malone".

Vera is often mentioned but never seen.

When Nicholas Colasanto died of a heart attack in 1985, Coach was written out as deceased.

In season 4, Woody Boyd, a not-so-bright bartender, arrives from his Midwest hometown of Hanover, Indiana to see Coach, his "pen pal". Sam tells Woody that Coach has died and hires him in Coach's place.

Sam, Cliff, Norm and Frasier decide to have a beard growing contest, judged by Carla and Rebecca on length, body, fullness, luster, sheen, bounce and the ever important beer absorption ability. The day before the end of the contest, Sam, Norm and Frasier's beards are looking full and lush, while Cliff's is still a little scraggly, but the day of the judging, Cliff miraculously comes in with a full beard, which he attributes the the Clavin genes of sporadic but quick hair growth.

In "Someone Single, Someone Blue", Coach explains that he earned his nickname by reading a book.

In "Homicidal Ham", Andy Andy returns to Cheers and holds up the bar because he can't make it as an actor and wants to go back to prison. But Diane, ever the humanitarian, decides to help him develop his acting skills by putting on a production of Othello.

Eddie was killed by a Zamboni when he saved the life of another member of the ice show. At the funeral, it is revealed that he has a secret second marriage to a woman named Gloria. Carla changes her surname back to Tortelli to avoid being confused with the other "Mrs. LeBec".

Sam has standing orders to have Harry the Hat (known for his signature fedora) thrown out of the bar on sight, but Harry sometimes helps the gang out--partly from sentiment, and partly to protect the Cheers gang from operators even more unscrupulous than himself. As Harry notes, "I don't like the idea of someone else plucking my pigeons."