Rick Grimes and Shane Walsh were both deputies in King County, Georgia. The county is fictitious and is named after horror writer Stephen King.

In the episode "Beside the Dying Fire", Michonne is introduced wearing a hood. Danai Gurira had not yet been cast in the role.

In "Still Gotta Mean Something", Negan tells Jadis "My wife's name was Lucille. She got me through. I didn't give her shit and she got me through...just life, regular life. The bat...the bat got me through this. That's why I named it after her. That's it. Nothing more to do with her than that. But it is the last little piece of her that I got left."

A total of sixteen actors, eight different sets of twins, have portrayed Lori's daughter and Carl's half-sister who was born in the third season episode "Killer Within".

According to TV Guide, the "human flesh" eaten on set is ham soaked in vinegar.

According to the promotional information for the tenth issue of the comic book "more is learned about the zombies that now out-number us 5000 to 1, but when it comes to some things, it's better not to know."

In the series premiere, Rick meets Morgan Jones after his son Duane mistakes Rick for a walker and hits him with a shovel.

Daryl Dixon was created specifically for actor Norman Reedus who originally auditioned for the role of Merle Dixon. The character does not have a counterpart in the comics on which the series is based.

When Steven Yeung put on a red baseball cap and windbreaker for his costume fitting, a costumer noted that he looked like Short Round, Indiana Jones' sidekick. The name made its way into the series in the episode "What Lies Ahead".

In 2005, Norman Reedus was in a horrible accident where his car was hit by an 18 wheeler and he was thrown out the window. He underwent multiple surgeries and now has a titanium eye socket and four metal screws in his nose.