George Clinton, one of the Founding Fathers of the United States, served as vice president under both Thomas Jefferson (1805-1809) and James Madison (1809-1812).

Aaron Burr, Thomas Jefferson's VP, shot and killed his political rival Alexander Hamilton in an 1804 duel. Although he was never tried for the illegal duel, Hamilton's death ended Burr's political career as Jefferson dumped him from the ticket in the next election.

The term gerrymandering is named after James Madison's VP, Elbridge Gerry, who, as Governor of Massachusetts in 1812, signed a bill that created a partisan district in the Boston area that was compared to the shape of a mythological salamander.

On June 15, 1992, Quayle altered 12-year-old student William Figueroa's correct spelling of "potato" to "potatoe" at the Muñoz Rivera Elementary School spelling bee in Trenton, New Jersey. He was the subject of widespread ridicule for his error.

Alben W. Barkley's grandson, Stephen M. Truitt, suggested the nickname "Veep" as an alternative to "Mr. Vice President". The nickname caught on with the press, but Barkley's successor, Richard Nixon, discouraged the use of it, saying it belonged to Barkley.

On his mother's side, Charles Curtis was a descendant of chief White Plume of the Kaw Nation and chief Pawhuska of the Osage.

John Adams, the second president of the United States, served as vice president under his predecessor, George Washington.

After his term as vice-president ended in 2001, Al Gore remained prominent as an environmental activist, whose work in climate change activism earned him (jointly with the IPCC) the Nobel Peace Prize in 2007.

Dick Cheney has been cited as the most powerful vice president in American history. He is also one of the most unpopular politicians in the history of the US, holding an approval rating of just 13% when he left office in 2009.

Thirty-six years old at the time of his inauguration on March 4, 1857, John C. Breckinridge was the youngest vice-president in U.S. history, exceeding the minimum age required under the Constitution by only a year.