Lt. Uhura does not appear in "Turnabout Intruder", the last episode of Star Trek: TOS. She is replaced by Lt. Lisa, who some fans have identified as "the night shift communications officer".

Jeri Ryan turned down the role of Seven of Nine four times; she only accepted the part after repeated lobbying by executive producer Jeri Taylor.

James Doohan ("Scotty") lost his right middle finger during WWII. Most of his scenes are shot to hide it. In scenes with a close-up view of Scotty's hands (operating the transporter for example) someone else's hands were always used. However, it is noticeable on a few rare occasions. The most obvious example is "The Trouble With Tribbles" when Scotty comes into the Rec Room with his arms filled with Tribbles. Take a close look at his hands. You can clearly see he's missing a finger.

During the Battle of Wolf 359, the U.S.S. Saratoga was destroyed, but the ship's first officer, Benjamin Sisko, escaped with his son. An estimated 11,000 people were killed during the battle, including Sisko's wife, Jennifer.

While guest-starring on the game show Super Password on January 7, 1987, Nichelle Nichols revealed that Uhura's first name was "Nyota". "Nyota" is the Swahili word for "star".

Troi is an avid connoisseur of chocolate. She once remarked that she had never met a chocolate she didn't like, and in one episode, she instructs Commander Riker in the fine art of eating chocolate.

Sulu is promoted to captain and given command of the U.S.S. Excelsior three years before the events of Star Trek VI: The Undiscovered Country.

In the series finale, chief engineer Charles "Trip" Tucker III sacrifices himself to save the rest of the crew.

Captain Picard suffers from a severe case of androgenic alopecia ... also known as male pattern baldness.

Captain Jonathan Archer helped forge an alliance between the formerly belligerent Vulcan, Andorian, and Tellarite states that culminated in a formal union in 2161. The Bajorans are a non-Federation species.