Victor Henriksen is an FBI agent who pursues the Winchesters, believing them to be serial killers. When he finally captures them and holds them in a small town jail, demons attack the station. Forced to accept the existence of the supernatural, Henriksen agrees to help Sam and Dean fight off the demon horde.
Dean dies over 100 times in one episode alone ("Mystery Spot") when he is trapped in Gabriel's time loop. Known causes of death include getting shot in the chest, being hit by a car, being crushed by a dresser, choking on a sausage, eating a bad taco, being electrocuted plugging in an electric razor, and accidentally being bludgeoned by an axe.
Genevieve Padalecki (nee Cortese) played Ruby in season four of Supernatural. She is also known for her role on the television series Wildfire as Kris Furillo. She and Jared started dating during the filming of season four and were married on February 27, 2010 in Sun Valley, Idaho.
Because perceiving his actual form typically results in blindness, the angel Castiel takes a human host -- James "Jimmy" Novak, a "devout man" who agrees to become a vessel for Castiel and remains so until Heaven takes Castiel back to Heaven for "re-indoctrination" after his superiors become concerned that he is becoming too close to humans -- Dean in particular.